Many other medications can interact with Avapro (Irbesartan), causing an increased risk of side effects or causing the medicine to be ineffective. Before you order Avapro at cheap prices online, you should tell your doctor if you are taking any other medications. Specifically, diuretics (water pills) can interact with this particular medicine. Apart from this, there may be other medications that can interact with Avapro. Do not hesitate to tell your doctor if you are using any other medications. This includes over-the-counter, herbal products, vitamins, and medicines prescribed by other doctors. It is important that you know about the drug interactions before you purchase Avapro, so that you can make sure to avoid any problems.